Peng Chen group - Publications

136

Han Y, Ma Y, Pei M, Yin S, Wang J, Guo L, Fang Y, Guo W, Deng C, Zhao S, Lu X, Xi J*, Zhang H*, Chen P*, “Intratumoral vaccine by checkpoint degradation-coupled antigen presentation”,Nature 2026, 650, 736–747  

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135

Zhu R, Zhang H*, Chen P*, “Targeted protein degradation in the transmembrane and extracellular space”, Science, (2025), DOI: 10.1126/science.adx5094 

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134

Gao Z, Li T, Ye H, Ngai WSC, Wang H, Chen P*, Wang J*. “A gasdermin-based life-death evolution system for reprogramming protease specificity”. Nat Chem Biol. (2025), DOI: 10.1038/s41589-025-02063-3.

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133

Yang Z, Jiang J, Cao Y, Fang H, Zhang X, Zhang Y, Zhang H*, Chen P*. “Cell-Selective Targeting Chimeras (SelecTACB) for Membrane Protein Degradation on B Cells”. J Am Chem Soc. (2025),147, 36301-9.

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132

Liu J, Yan X, Wu H, Ji Z, Shan Y, Wang X, Ran U, Ma Y, Li C, Zhu Y, Gu R, Han W, Yi C*, Chen P*, “RNA codon expansion via programmable pseudouridine editing and decoding”, Nature, (2025), 643, 1410-20.

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131

Wang X, Liu Y, Wang Z, Zeng X, Ngai WSC, Wang J, Zhang H, Xie X, Zhu R, Fan X, Wang C*, Chen P*, “Machine-learning-assisted universal protein activation in living mice”, Cell, (2025),188, 3696-3714.

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130

Bi Y, Yu L, Deng Q, Kong L, Guo F, Zhang Y, Wang R, Chen P* Liu J,* Fan X*, “Photocatalytic Proximity Labeling-Enabled Subcellular-Resolved RNA Profiling and Synchronous Multi-omics Investigation.” Nat. Chem. (2025), DOI: 10.1038/s41557-025-01946-1.

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129

Zhou N, Zhang Y, Chen P*, Fan X*, “Time-Resolved Photocatalytic Proximity Labeling Uncovers ER Proteome Dynamics Underlying UPR to Apoptosis Transition.” PNAS (2025), DOI: 10.1073/pnas.2503115122.

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128

Li K, Xie X, Gao R, Chen Z, Yang M, Wen Z, Weng Y, Fan X, Zhang G, Liu L, Zeng X, Han Y, Cao M, Wang X, Li J, Yang Z, Li T, Chen P*, “Spatial-temporal protein interactome profiling through condensation enhanced photo-crosslinking”, Nat. Chem., (2025), 17, 111-23.

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127

Liu Z, Zhang Y, Fan X*, Chen P*, “Chemical Decoding of Spatial Biology”, Nat. Chem. Biol. (2025), DOI: 10.1038/s41589-025-01910-7.

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126

Zhu Y, Lin F, Liu Z, Wang X, Wang S, Fan X*, Chen P*, “Bioorthogonal Cleavage Chemistry: Harnessing the Bond-Break Reactions for Biomolecule Manipulations in Living Systems”, Chin. J. Chem. (2025), 43, 553-566

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125

Lou Z, Zhang Y, Liang X, Cao M, Ma Y, Chen P*, Fan X* “Deep-Red and Ultrafast Photocatalytic Proximity Labeling Empowered in situ Dissection of Tumor-Immune Interactions in Primary Tissues.” J. Am. Chem. Soc. (2025), 9716-26.

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124

Zhang Y, Liu Z, Zhou N, Guo F, Guo H, Chen X, Chen P*, Fan X*, “In situ Lysosomal Proteomics Enabled by Bioorthogonal Photocatalytic Proximity Labeling.” Nat. Catal. (2025), 162-77

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123

Lin F, Yin S, Zhang Z, Yu Y, Fang H, Liang Z, Zhu R, Zhou H, Li J, Cao K, Guo W, Qin S, Zhang Y, Lu C, Li H, Liu S, Zhang H, Ye B, Lin J*, Li Y*, Kang X*, Xi J*, Chen P*, “Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment”, Cell, (2024), 187, 7470-91.

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122

Liu H, Fu Z, Han Y, Fang Y, Shen W, Chen Z, Zhu R, Zhang H*, Chen P*, “Conditionally activatable chimeras for tumor-specific membrane protein degradation”, J. Am. Chem. Soc. (2024),146, 32933-41.

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121

Zhang Y, Liu S, Guo F, Qin S, Zhou N, Fan X*, Chen P*, “Bioorthogonal quinone methide decaging enables live-cell quantification of tumor-specific immune interactions.” J. Am. Chem. Soc. (2024), 146, 15186-97.

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120

Zhu Y, Ding W, Fan X*, Lin S*, Chen P*, “Genetically encoded bioorthogonal tryptophan decaging in living cells”, Nat. Chem., (2024), 16, 533-42.

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119

Liu Z, Guo F, Zhu Y, Qin S, Hou Y, Lin F, Guo H, Chen P*; Fan X*, “Bioorthogonal photocatalytic proximity labeling in primary living samples.” Nat. Commun. (2024), 15, 2712.

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118

Weng Y, Chen W, Kong Q, Wang R, Zeng R, He A, Liu Y, Mao Y, Qin Y, Ngai WSC, Zhang H, Wang J, Ke M, Tian R*, Chen P*. “DeKinomics pulse-chases kinase functions in living cells”, Nat. Chem. Biol. (2024), 20, 615-23.

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117

Guo W, Liu Y, Han Y, Tang H, Fan X, Wang C*, Chen P* “Amplifiable protein identification via residue-resolved barcoding and composition code counting”, Natl. Sci. Rev. (2024), 11, nwae183.

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116

Zhang X, Huang H, Liu Y, Wu Z, Wang F, Fan X, Chen P*, Wang J*, “Optical control of protein functions via genetically encoded photocaged aspartic acids”, J. Am. Chem. Soc. (2023),145, 19218-24.

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115

Guo F, Qin S, Liu Z, Chen P*, Fan X*, “Decaging-to-labeling: Development and investigation of quinone methide warhead for protein labeling.” Bioorg. Chem. 2024, 143, 107088

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114

Liang X Qian S, Lou Z, Hu R, Hou Y, Chen P*, Fan X*, “Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice.” Angew. Chem. Int. Ed. 2023, 62:e202310920.

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113

Wu XY, Li MY, Yang SJ, Jiang J, Ying Y*, Chen P*, Long Y. “Controlled genetic encoding of unnatural amino acids in a protein nanopore”. Angew. Chem. Int. Ed. (2023), 62:e202300582.

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112

Qin F*, Li B, Wang H, Ma S, Li J, Liu S, Kong L, Zheng H, Zhu R, Han Y, Yang M, Li K, Ji X*, Chen P*. “Linking chromatin acylation mark-defined proteome and genome in living cells”, Cell, (2023), 186, 1066-85. 

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111

Liu Z, Xie X, Huang Z, Lin F, Liu S, Chen Z, Qin S, Fan X*, Chen P*. “Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging”. Chem. (2022), 8, 2179-91.

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110

Luo H, Tang W, Liu H, Zeng X, Ngai WSC, Gao R, Li H, Li R, Zheng H, Guo J, Qin F, Wang G, Li K, Fan X, Zou P*, Chen P*. “Photocatalytic chemical crosslinking for profiling RNA-protein interactions in living cells”, Angew. Chem. Int. Ed. (2022), 61:e202202008. 

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109

Liu H, Luo H, Xue Q, Qin S, Qiu S, Liu S, Lin J, Li JP*. Chen, P*, “Antigen-specific T cell detection via photocatalytic proximity cell labeling (PhoXCELL)”. J. Am. Chem. Soc. (2022), 144, 5517-26.

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108

Ngai WSC, Yang S, Zeng X, Liu Y, Lin F, Wang X, Zhang H, Fan X*, Chen P*. “Bioorthogonally activatable base editing for on-demand pyroptosis”. J. Am. Chem. Soc. (2022). 144, 5411-17.

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107

Han Y, Yang Z, Hu H, Zhang H, Chen L, Li K, Kong L, Wang Q, Liu B, Wang M*, Lin J*, Chen P*. “Covalently engineered protein minibinders with enhanced neutralization efficacy against escaping SARS-CoV-2 variants”. J. Am. Chem. Soc. (2022). 144, 5702-07.

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106

Huang Z, Liu Z, Xie X, Zeng R, Chen Z, Kong L, Fan X*, Chen P*. “Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics”, J. Am. Chem. Soc. (2021), 143, 18714-20.

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105

Zhang H, Han Y, Yang Y, Lin F, Lin J*, Chen P*. “Covalently engineered nanobody chimeras for targeted membrane protein degradation”. J. Am. Chem. Soc. (2021), 143, 16377-82

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104

Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*. “SAR1B senses leucine levels to regulate mTORC1 signalling”, Nature, (2021), 596, 281-4.

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103

Wang J, Liu Y, Liu Y, Wang C*, Chen P*. “CAGE-prox: A unified approach for time- resolved protein activation in living systems”, Curr. Proto., (2021), e180. DOI: 10.1002/cpz1.180. 

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102

Liu Y, Zeng R, Wang R, Weng Y, Wang R, Zou P*, Chen P*. “Spatiotemporally resolved subcellular phosphoproteomics”, Proc. Natl. Acad. Sci. USA. (2021), 118, e2025299118.

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101

Yang S, Ngai WSC, Chen P*. “Chemical engineering of bacterial effectors for regulating cell signaling and responses”, Curr Opin Chem Biol. (2021), 64, 48-56.

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100

Wang, J, Wang, X. Fan, X*. Chen P*. “Unleashing the power of bond cleavage chemistry in living systems”, ACS Cent. Sci. (2021), 7, 929-43.

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99

Liu S, Lin C, Xu Y, Luo H, Peng L, Zeng X, Zheng X, Chen P*, Zou P*. “A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons”, Nat. Chem. (2021), 13,472–9. 

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98

Zhu R, Zhang G, Jing M, Han Y, Li J, Zhao J, Li Y, Chen P*. “Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction”, Nat. Commun. (2021), 12, 581.

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97

Zhang X, Luo H, Fan X*, Chen P*. “Development and application of inverse-electron-demand Diels-Alder reaction in biorthogonal chemistry”. Sci. Sin. Chim. (2020), 50,1280-95. 

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96

Chen L, Liu B, Sun P, Wang W, Luo S, Zhang W, Yang Y, Wang Z, Lin J*, Chen P*. “Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Nanogel as a Pro-Antigen Strategy with Enhanced Protective Immune Responses”. Small. (2020), 16, e2004237.

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95

Li J, Wang YN, Xu BS, Liu YP, Zhou M, Long T, Li H, Dong H, Nie Y, Chen P, Wang ED*, Liu RJ*. “Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs”. EMBO Rep. (2020), 21, e50095.

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94

Yu R, Wu H, Ismail H, Du S, Cao J, Wang J, Ward T, Yang F, Gui P, Ali M, Chu L, Mo F, Wang Q, Chu Y, Zang J, Zhao Y, Ye M, Fang G, Chen P, Dou Z, Gao X, Wang W, Liu X, Yao X. “Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics”. J Mol Cell Biol. (2020), 12, 462-76.

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93

Yang S, Tang Q, Chen L, Chang J, Zhao J,Jiang T, Wang M,* Chen P*. “Cationic Lipid-based Intracellular Delivery of Bacterial Effectors for Rewiring Malignant Cell Signaling”, Angew. Chem. Int. Ed. (2020), 59, 18087-94. 

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92

Zheng H, Lin S, Chen P*. “Genetically encoded protein labeling and crosslinking in living Pseudomonas aeruginosa”. Bioorg Med Chem. (2020), 28, 115545.

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91

Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen P*. “SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference”, Cell Chem. Biol. (2020), 27, 283-91.

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90

Wang X, Liu Y, Fan X, Wang J, Ngai WSC, Zhang H, Li J, Zhang G, Lin J*, Chen P*. “Copper-triggered bioorthogonal cleavage reactions for reversible protein and cell surface modifications”, J. Am. Chem. Soc. (2019), 141, 17133-41.

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89

Wang J, Liu Y, Liu YJ, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C*, Chen P*. “Time-resolved protein activation by proximal decaging in living systems”. Nature, (2019), 569, 509-13.

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88

Lin F, Chen L, Zhang H, Ngai W, Zeng X, Lin J, Chen P*, “Bioorthogonal prodrug–antibody conjugates for on-target and on-demand chemotherapy”, CCS Chem., (2019), 1, 226-36.

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87

Chen L, Zeng D, Xu N, Li C, Zhang W, Zhu X, Gao Y, Chen P, Lin J*. Blood-brain barrier- and Blood-brain tumor barrier-penetrating peptide-derived targeted therapeutics for glioma and malignant tumor brain metastases. ACS Appl Mater Interfaces. (2019), 11, 41889-97.

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86

Wang C, Zou P, Yang C, Liu L, Cheng L, He X, Zhang L, Zhang Y, Jiang H*, Chen P*. “Dynamic modifications of biomacromolecules: mechanism and chemical interventions”. Sci China Life Sci. (2019) 62, 1459-71.

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85

Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen P*. “Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions”, J. Am. Chem. Soc. (2019), 141, 1833-7.

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84

Zhao J, Liu Y, Lin F, Wang W, Yang S, Ge Y, Chen P*. “Bioorthogonal engineering of bacterial effectors for spatial–temporal modulation of cell signaling”, ACS Cent. Sci. (2019), 5, 145-53.

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83

He D, Zhang M, Liu S, Xie X, Chen P*. “Protease-mediated protein quality control for bacterial acid resistance”, Cell Chem. Biol. (2019), 26,144-50.

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82

Yao Q, Lin F, Fan X, Wang Y, Liu Y, Liu Z, Jiang X, Chen P*, Gao Y*.“Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems”, Nat. Commun. (2018), 9, 5032.

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81

Hao Z, Zhu R, Chen P*.“Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems”, Curr. Opin. Chem. Biol. (2018), 43, 87-96.

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80

Ngai WSC, Chen P*. “Optimizing orthogonality”. Nat Chem. (2018), 10, 802-3.

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79

Liu L, Liu Y, Zhang G, Ge Y, Fan X, Lin F, Wang J, Zheng H, Xie X, Zeng X, Chen P*. “Genetically encoded chemical decaging in living bacteria”, 1 Biochemistry. (2018), 57, 446-50.

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78

Zheng H, Lin S, Chen P*. “Genetic code expansion in enteric bacterial pathogens”, Methods Mol Biol. (2018), 1728, 113-26.

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77

Hao Z, Zhu R, Chen P*. “Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems”, Curr Opin Chem Biol. (2018), 43, 87-96. 

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76

Duan H-C, Wei L-H, Zhang C, Wang Y, Chen L, Lu Z, Chen P, He C*, Jia G*. “ALKBH10B is an RNA N6-methyladenosine demethylase affecting Arabidopsis floral transition”, Plant Cell (2017), 29, 2995-3011.

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75

Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen P*. “An allosteric histidine switch for regulation of intracellular zinc(II) fluctuation”, Proc. Natl. Acad. Sci. USA. (2017), 114, 13661-13666.

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74

Wang J, Chen P*.“The development and applications of bioorthogonal cleavage reactions”, Acta Chim. Sinica (2017), 75, 1173-82.

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73

He D, Xie X, Yang F, Zhang H, Su H, Ge Y, Song H, Chen P*. “Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker”, Angew. Chem. Int. Ed. (2017), 56, 14521-5. 

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72

Xie X, Li X, Qin F, Lin J, Zhang G, Zhao J, Bao X, Zhu R, Song H, Li X*, Chen P*. “Genetically encoded photoaffinity histone marks”, J. Am. Chem. Soc. (2017), 139, 6522-5.

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71

Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen P*.“ Genetically encoded releasable photocrosslinking strategies for studying protein-protein interactions in living cells”, Nat. Protocol. (2017), 12, 2147-68.

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70

Zheng S, Fan X, Wang J, Zhao J, Chen P*. “Dissection of kinase isoforms via orthogonal and chemical inducible signaling cascades”, ChemBioChem. (2017), 18, 1593-8.

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69

Lin Z, Xie X, Chen P*. “Kicking down the ladder: adding cleavable features to genetically encoded photocrosslinkers”, Sci. Sinica Chim. (2017), 60, 167-9.

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68

Zhang S, He D, Lin Z, Yang Y, Song H, Chen P*.“Conditional chaperone-client interactions revealed by genetically encoded photocrosslinkers”, Acc. Chem. Res. (2017), 50, 1184-92.

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67

Fan X, Li J, Chen P*. “Bioorthogonal chemistry in living animals”, Natl. Sci. Rev. (2017), 4, 300-02.

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66

Zhu R, Hao Z, Lou H, Song Y, Zhao J, Chen Y, Zhu J, Chen P*. “Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator”, J. Biol. Inorg. Chem. (2017), 22, 685-93.

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65

Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J, Chen P*. “Palladium-triggered chemical rescue of intracellular proteins via genetically encoded allene-caged tyrosine”, J. Am. Chem. Soc. (2016), 138, 15118-21.

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64

Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S, Chen P*. “Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance”, Proc. Natl. Acad. Sci. USA. (2016), 113, 10872-7.

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63

Fan X, Ge Y, Lin F, Yang Y, Zhang G, Ngai W, Lin Z, Zheng S, Wang J, Zhao J, Li J, Chen P*. “Optimized tetrazine derivatives for rapid bioorthogonal decaging in living cells”, Angew. Chem. Int. Ed. (2016), 55, 14046-50.

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62

Yang Y, Song H, Chen P*.“Genetically encoded photocrosslinkers for identifying and mapping protein-protein interactions in living cells”, IUBMB Life (2016), 68, 879-86.

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61

Ge Y, Fan X, Chen P*. “A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells”, Chem. Sci. (2016), 7, 7055-60.

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60

Chen L, Cohen J, Song X, Zhao A, Ye Z, Feulner C, Doonan P, Somers W, Lin L*, Chen P*. “Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency”, Sci. Rep. (2016), 6, 31899. 

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59

Yang Y, Song H, He D, Zhang S, Dai S, Lin S, Meng R, Wang C*, Chen P*. “Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label”, Nat. Commun. (2016), 7, 12299.

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58

Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen P*. “Bioorthogonal chemical activation of kinases in living systems”, ACS Cent. Sci. (2016), 2, 325-31. [This work has been highlighted by Chem. & Eng. News, 2016, 94(19), 5]

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57

Li J, Chen P*. “Development and application of bond cleavage reactions in bioorthogonal chemistry”, Nat. Chem. Biol. (2016), 12, 129-37. 

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56

Yang M*, Yang Y, Chen P*.“Transition-metal-catalyzed bioorthogonal cycloaddition reactions”, Top. Curr. Chem. (2016), 374, 27-55. 

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55

Song Y, Yang M, Wegner S, Zhao J, Zhu R, Wu Y, He C*, Chen P*. “A genetically encoded FRET sensor for intracellular Heme”, ACS Chem. Biol. (2015), 10, 1610-5.

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54

Song Y, Zhu R, Chen P*. “Physiological distribution and regulation of heme”, Sci. Sinica Chim. (2015), 45, 1194-205.

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53

Wang J, Cheng B, Chen X*, Chen P*. “Chemically remodeling of cell-surface sialic acids by using the palladium-triggered bioorthogonal elimination reactions”, Angew. Chem. Int. Ed. (2015), 54, 5364-8.

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52

Hackenberger C*, Chen P*. “Synthetic biomolecules: Synthetic protein modifications-a giant leap towards understanding and generating biological functions”, Curr. Opin. Chem. Biol. (2015), 28, vii–ix.

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51

Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen P, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J*. “6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signaling”, Nat. Cell Biol. (2015), 11, 484-96.

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50

Zhang G, Zheng S, Chen P*. “Illuminating biological processes through site-specific protein labeling”, Chem. Soc. Rev. (2015), 44, 3405-17. (Invitation for Emerging Investigator Lectureship Award 2014).

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49

Yang M, Chen P*. “Progress in the bioorthogonal labeling reactions”, Acta. Chim. Sinica, (2015), 73, 783-92.

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48

Li J, Jia S, Chen P*. “Diels-Alder reaction-triggered bioorthogonal protein activation in living cells”, Nat. Chem. Biol., (2014), 10, 1003-5.[This work has been highlighted by Nature Methods, 2015, 12,16 ]

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47

Yang M, Jolloh A, Wei W, Zhao J*, Wu P*, Chen P*. “Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli”, Nat. Commun. (2014), 5, 4981.[This work has been highlighted by Chem. & Eng. News. 2014, 92(39), 30]

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46

Lin S, He D, Long T, Zhang S, Meng R, Chen P*. “Genetically encoded cleavable protein photocrosslinker”, J. Am. Chem. Soc. (2014), 136, 11860-3.[This work has been highlighted by Chem. & Eng. News. 2014, 92(34), 4]

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45

Lin S, Chen P*. “Virus engineering: fighting HIV at its own game”, Nat. Chem. (2014), 6, 566-8.

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44

Zheng S, Zhang G, Li J, Chen P*. “Monitoring endocytic trafficking of anthrax lethal factor via precise and quantitative protein labeling”, Angew. Chem. Int. Ed. (2014), 53, 6449-53.

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43

Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P*. “Palladium-triggered deprotection chemistry for protein activation in living cells”, Nat. Chem. (2014), 6, 352-61. [This work has been highlighted by Nature Chemical Biology,2014,10,328, Nature Methods, 2014,11,472 ]

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42

Yang M, Li J, Chen P*. “Transition metal mediated biocompatible protein chemistry in living cells”, Chem. Soc. Rev. (2014), 43, 6511-26. Emerging Investigators Special Issue.

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41

Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao B, Zeng S, Chen X, Chan J, He C*, Chen P*. “The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli”, Nat. Chem. Biol. (2014), 10, 21-8. [This work has been highlighted by (RSC) Chemistry World]

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40

Yang Y, Lin S, Lin W, Chen P*. “Ligand-assisted dual-site click labeling of EGFR on living cells”, ChemBioChem. (2014), 15, 1738-43.

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39

Ming Cheng, Wei Zhang, Jinghe Yuan, Wangxi Luo, Nan Li, Shixian Lin, Yi Yang, Xiaohong Fang*, Chen P*. “Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells”, Chem. Comm. (2014), 50, 14724-7.

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38

Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen P, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J*. “Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth”, Mol. Cell. (2014), 55, 552-65.

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37

Fan Y, Zhao J, Yan Q, Chen P* and Zhao D*. “A water-soluble triscyclometalated oganoiridium complex: phosphorescent nanoparticle formation, nonlinear optics, and application for cell imaging”. ACS Appl. Mat. Inter. (2014), 6, 3122-31.

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36

Ge X, Wang R, Ma J, Liu Y, Ezemaduka AN, Chen P, Fu X*, and Chang Z*. “DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli”, FEBS J. (2014), 281, 1226-40.

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35

Li J, Lin S, Wang J, Jia S, Yang M, Zhang X, Hao Z, Chen P*. “Ligand-free palladium-mediated site-specific protein labeling inside Gram-negative bacterial pathogens”, J. Am. Chem. Soc. (2013), 135, 7330-8.

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34

Zhao J, Lin S, Huang Y, Zhao J*, Chen P*. “Mechanism-based design of a photoactivatable firefly luciferase”, J. Am. Chem. Soc. (2013), 135, 7410-3.

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33

Lin S, Yan H, Li L, Yang M, Peng B, Chen S, Li W*, Chen P*. “Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus”, Angew. Chem. Int. Ed. (2013), 52, 13970-4.

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32

Chang H, Han M, Huang W, Wei G, Chen J, Chen P, Chen R, Zhang J, Xu T*, Xu P*. “Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans”, Protein Cell. (2013), 4, 883-6.

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31

Zhao B, Zhang G, Zeng S, He C, and Chen P*. “Probing subcellular organic hydroperoxide  formation via a genetically encoded ratiometric and reversible fluorescent indicator”, Integr. Biol. (2013), 5, 1485-9.

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30

Liu J, Karpus J, Wegner S, Chen P*, He C*. “Genetically encoded copper(I) reporters with improved responses for use in imaging”, J. Am. Chem. Soc. (2013), 135, 3144-9.

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29

Yang M, Song, Y, Zhang M, Lin S, Hao Z, Liang Y, Zhang D, Chen P*.

“Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity”, Angew. Chem. Int. Ed. (2012), 51, 7674-9.

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28

Li Y, Yang M, Huang Y, Song X, Liu L,* Chen P*. “Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling”, Chem. Sci. (2012), 3, 2766-70.

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27

Li J, Chen P*.“Moving pd-mediated protein cross-coupling to living systems”, ChemBioChem. (2012), 13, 1728-31.

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26

Wang J, Karpus J, Zhao B, Luo Z, Chen P, He C*. “A selective fluorescent probe for carbon monoxide imaging in living cells”, Angew. Chem. Int. Ed. (2012), 51, 9652-6.

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25

Li Y, Yang M, Huang Y, Chen, P*, Liu L*. “Ligation of expressed protein α-Hydrazides via genetic incorporation of an α-hydroxy acid”, ACS Chem. Biol. (2012), 7, 1015-22.

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24

Wei W, Zhu T, Wang Y, Yang H, Hao Z, Chen P*, Zhao J*. “Engineering a gold-specific regulon for cell-basedvisual detection and recovery of gold”, Chem. Sci. (2012), 3,

1780-4.

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23

Liu J, Zhang M, Chen P*. “Probing pH mediated protein-protein interactions via photocrosslinking”, Sci. Sinica Chim. (2012), 42, 1694-9.

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22

Li J, Wang J, Chen P*. “Unnatural amino acid mediated protein bioorthogonal labeling”, Acta. Chim. Sinica (2012), 70, 1439-45. 

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21

Chen X, Hao Z, Chen P*. “Protein photocrosslinking reveals dimer of dimers formation on MarR protein in Escherichia coli”, Sci. China Chemistry (2012). 42, 223-5.

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20

Zhang M, Lin S, Song X, Liu J, Fu Y, Fu X, Chang Z*, Chen P*. “A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance”, Nat. Chem. Biol. (2011), 7, 671-7. [This work is a “News Coverage” on Chem. & Eng. News. 2011, 89(37), 10; and has been highlighted by Nature Asia-Pacific on Sep 5, 2011 ]

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19

Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z, Chen P*. “Site-specific incorporation of photocrosslinker and bioorthogonal amino acids into enteric bacterial pathogens”, J. Am. Chem. Soc. (2011), 133, 20581-7.

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18

Hao Z, Song Y, Lin S, Yang M, Liang Y, Wang J, Chen P*. “A readily synthesized cyclic pyrrolysine analogue for site-specific protein ‘click’ labeling”, Chem Commun (Camb) (2011), 47, 4502-4.

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17

Hao Z., Hong S, Chen X*, Chen P*. “Introducing bioorthogonal functionalities into proteins in living cells”, Acc. Chem. Res. (2011), 44, 742-51.

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16

Chen P*, Brugarolas P, He C*. “Redox signaling in human pathogens”, Antioxid. Redox. Signal. (2011), 14, 1107-18.

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15

Zhao B, Liang Y, Song Y, Zheng C, Hao Z, Chen P*. “A highly selective fluorescent probe for visualization of organic hydroperoxides in living cells”, J. Am. Chem. Soc. (2010), 132, 17065-7.

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14

Zhao J, Chen P*. “Discovery of mystery in ribosome-introduction of the 2009 Nobel Prize in Chemistry”, Univ. Chem. (2009), 24, 1-5. 

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13

Chen P, Dan G, Guo J, Ou W, Geierstanger B, Schultz PG. “A facile system for encoding unnatural amino acids in mammalian cells”, Angew Chem. Int. Ed. (2009), 48, 4052-5.

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12

Ai H, Shen W, Sagi A, Chen P, Schultz PG. “Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid”, ChemBioChem. (2011), 12, 1854-7.

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11

Dan G, Chen P, Peters F, Schultz PG. “A genetically encoded epsilon-N-methyl lysine in mammalian cells”, ChemBioChem (2010), 11, 1066-8.

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10

Chen P, Nishida S, Poor C, Cheng, A, Bae T, Kuechenmeister L, Dunman P, Missiakas D, He C. “A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus”, Mol. Microbiol. (2009), 71, 198-211.

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9

Poor C, Chen P, Duguid E, Rice P, He C. “Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus”, J. Biol. Chem. (2009), 284, 23517-24.

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8

Chen P, He C. “Selective recognition of metal ions by metalloregulatory proteins”, Curr. Opin. Chem. Biol. (2008), 12, 214-21.

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7

Chen H, Hu J, Chen P, Lan L, Li Z, Hicks L, Dinner A, He C. “The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation sensing mechanism”, Proc. Natl. Acad. Sci. USA. (2008), 105 , 13586-91.

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6

Chen P, Wasinger E, Zhao J, van der Lelie D, Chen L, He C. "Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691", J. Am. Chem. Soc. (2007), 129, 12350-1.

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5

Sarkar S, Andoy N, Benitez J, Chen P, Kong J, He C, Chen P. "Engineered holliday junctions as single-molecule reporters for protein-DNA interactions with application to a MerR-family regulator", J. Am. Chem. Soc. (2007), 129, 12461-7.

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4

Wegner S, Okesli A, Chen P, He C “Design of an emission ratiometric biosensor from MerR family proteins: A sensitive and selective sensor for Hg2+”, J. Am. Chem. Soc. (2007), 129, 3474-5.

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3

Chen P, Bae T, Williams W, Duguid E, Rice P, Schneewind O, He C. “An oxidation sensing mechanism is used by a global regulator MgrA in Staphylococcus aureus”, Nat. Chem. Biol. (2006), 2, 591-5. [A Science and Technology Concentrate highlighting this work appears in Chem. & Eng. News 84 [41] 31 (2006). The finding described in this paper had also been registered in the Infectious Disease Biomarker Database as a potential biomarker for Staphylococcus aureus vancomycin resistance.]

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2

Chen P, Greenberg B, Taghavi S, Romano C, van der Lelie D, He C. “An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe”, Angew Chem. Int. Ed. (2005), 44, 2715-9. [This work had been highlighted by Chem. & Eng. News 83 [15] 26 (2005); Brookhaven National Laboratory News, April 4, 2005; and several German based newspapers.]

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1

Chen P, He C. “Constructing highly sensitive and selective fluorescent biosensors for metal ions by using the MerR family proteins”, J. Am. Chem. Soc. (2004), 126, 728-9.

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